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Dermatology and immunopathology unit |
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 Dr. Ignacio Umbert
Dr. Badal
The Unit's aim is to diagnose skin diseases, studied under the microscope and analysed jointly with a dermatologist and a pathologist.
A skin biopsy, in any of its different forms, is the complementary test that provides the best results in diagnosing skin diseases. |
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Interpreting most skin biopsies requires identifying and integrating two different morphological patterns: tissue reaction and inflammation patterns. Tissue reaction patterns are characteristic morphological patterns that distinguish a group of skin diseases.
A particular histopathological pattern can correspond to several types of diseases with similar or different clinical appearances and ethiology.
Biopsies are studied using the conventional technique of embedding samples in paraffin, having first stained them with the universal colorant eosin-hematoxilin. We also have an auxiliary automated battery of histochemical techniques for studying collagen, muscular, elastic and reticulin fibres, identifying bacteria, fungi and parasites, and acid and neutral mucosubstances.
We use the technique of direct immunofluorescence in material processed with a cryostat to identify and filiate bullous diseases, cutaneous vasculitis and autoimmune diseases such as connectivopathies, lupus erythematosus and dermatomyositis.
The Dermatology Unit has several immunohistochemistry panels integrated as routine automated techniques for differential diagnosis of tumours such as Merkel Cell Carcinoma, Paget's disease, Fibrohistiocytic tumours, mesenchymal neoplasies, pigmented lesions and lymphoproliferative processes with different monoclonal antibodies.
Immunohistochemistry techniques are also useful to identify the cell causing the lesion, such as the Langerhans cell. Immunohistochemistry techniques are helpful in differentially diagnosing some pigmented lesion entities such as fusocellular or desmoplastic melanoma, naevoid melanomas, scar vs. melanoma, etc.
Our Unit has staff trained to perform Mohs microsurgery with the study of margins in lesions such as basal cell and squalous carcinomas. This technique involves a plastic surgeon, a pathologist and a registered nurse/graduate in pathological anatomy.
Dermatopathology Unit:
· Microscopic study of cutaneous lesions assisted by a dermatologist and a pathologist
· Automated histochemical techniques
· Automated immunohistochemistry techniques
· Direct immunofluorescence
· Mohs microsurgery performed by a plastic surgeon and a pathologist
· Study of the sentry ganglion using a therapeutic protocol for malignant melanoma
For more information, please contact us through the following form. |
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